Diablo 4: How and When to Sanctify Items in Season 11

Diablo 4 Season 11 introduces one of Diablo 4 Items the most impactful crafting updates the game has seen to date: Sanctification. Positioned as the final and most powerful stage of gear progression, this new system allows players to push a single item to its absolute limit through irreversible, celestial-level upgrades.

This guide breaks down everything players need to know about the new system for maximum value and minimum gear-bricking risk.

What Is Sanctification in Diablo 4 Season 11?

Sanctification is a new progression system arriving with Diablo 4 Season 11. It acts as a one-time, irreversible enhancement that locks in your gear forever, preventing all further modifications except for socketing Gems and Runes.

Once Sanctified, an item can no longer be:

Tempered
Masterworked
Enchanted

Because of this, Sanctification is the final step in item crafting. You must complete all normal upgrade routes before applying this celestial infusion.

What Happens When an Item Is Sanctified?

Sanctifying a piece of gear can trigger multiple powerful effects:

Add a bonus Legendary Aspect.
Upgrade an existing affix into a Greater Affix.
Add a new Sanctification-exclusive affix (e.g., global skill bonuses, CDR, attack speed)
Replace one existing affix with a random Sanctification affix.
Add 5-25 Quality as a bonus roll.l
Rare chance to gain a Unique or even a Mythic power

PTR testing initially showed inconsistent rolls, but Blizzard confirmed increased odds for high-value outcomes in the final patch. This means Season 11 players will enjoy more reliable chances at elite affixes during Sanctification.

Overall, the system is high-risk, high-reward, with buy duriel mats the potential to create some of the strongest items in Diablo 4 history.